Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia

Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic haplotypic association of COMT rs4680 rs4618 polymorphisms severity other clinical symptoms 544 male 385 female subjects schizophrenia. rs4818 G carriers were more frequent patients mild abstract thinking difficulties, compared to CC homozygotes or C allele carriers. Male A had worse (N5) scores than GG carriers, whereas AA lower on intensity somatic concern (G1) item, rs4818–rs4680 GA haplotype highest G1 item (somatic concern), lowest G2 (anxiety) G6 (depression) items. was less severe disturbance volition (G13 item) group symptoms, while CG then symptoms. These findings suggest sex-specific a